Chilli Cure for Cancer

[Jessie]

Take your pick.....prostate cancer or stomach cancer ??? ???

http://www.thesun.co.uk/article/0,,2...20245,,00.html

[Aardvark]

Oh how the Sun seeks to inform.

This is as you guessed a bollocks story.

Human cancer cells in mice?? This is a long way off phase 1 testing.

The link between chillis and gastric CA is quite complex. Again we are faced with a multi factorial disease and any causality neerds to be studied carefully. If chilli consumption was linked to gastric carcenoma we would expect to see epidemiologically a higher incidence in sub populations following this diet when compared with a comparitor group matched for ethnicity, socila class, age, tobacco consumption, alcohol consumption etc. I have not read of such multi variate comparison.

We do know that in the UK Capsiacin is licened by the MHRA for the topical relief of muscular skeletal pain associated with osteoarthritis. Probably working by placing a counter irritant effect on the skin and closing off the sensory gate. See Melzac and Wall's gate control theory of spinal nerve afferent sensory transmittion.

On a lighter note, I think chillis are possibly a good anti depressant as the world always seems a better place to me when I have a belly full of hot curry :P

[Mongrel]

On a lighter note, I think chillis are possibly a good anti depressant as the world always seems a better place to me when I have a belly full of hot curry :P

Or the morning after when you're thinking "It can't get any worse than this!"

[vbloke]

Keep the toilet roll in the fridge for such an occasion

[tkingdoll]

Years ago I read something that chillis kill renewable brain cells in the same way that alcohol does. Does anyone know if there's any truth to that?

[Aardvark]

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract

Involvement of caspase cascade in capsaicin-induced apoptosis of dorsal root ganglion neurons.

Jin HW, Ichikawa H, Fujita M, Yamaai T, Mukae K, Nomura K, Sugimoto T.

Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan.

Capsaicin induces apoptosis in some types of neurons, but the exact molecular mechanism remains unclear. In this study, capsaicin was systemically administrated in newborn rats and the dorsal root ganglion (DRG) neurons were examined for caspase-immunoreactivity. Capsaicin-induced neuronal apoptosis was revealed by TUNEL. TUNEL-positive neurons rapidly increased, reaching the peak at 24 h post-injection when 10.6% of DRG neurons were apoptotic. Neurons expressing immunoreactivity for activated caspases-9 and -3 concomitantly increased. At 24 h, 15.9% and 17.7% of DRG neurons exhibited immunoreactivity for caspase-9 and caspase-3, respectively. DNA fragmentation signal and caspase-immunoreactivity were detected in less than 0.5% of DRG neurons of vehicle control rats. The immunoreactivity and TUNEL-positivity returned to the vehicle control level by 120 h. Double label immunohistochemistry revealed co-expression of caspase-9 and DNA fragmentation or caspase-3 and DNA fragmentation. These results suggest that the caspase cascade is involved in the primary neuronal apoptosis induced by neurotoxin capsaicin.

PMID: 16125681 [PubMed - indexed for MEDLINE]

This study looks at Injecting the active chemical from Chillis, capsiacin via an intravenous route into newborn rats.

Apoptosis means programmed cell death.

Conclusion, if you want your pet rat to have all its faculties, do not inject it with chilli extract soon after birth

[Aardvark]

http://www.liebertonline.com/doi/abs...jmf.2004.7.267

Journal of Medicinal Food
Capsaicin, a Spicy Component of Hot Pepper, Induces Apoptosis by Activation of the Peroxisome Proliferator-Activated Receptor γ in HT-29 Human Colon Cancer Cells
Sep 2004, Vol. 7, No. 3: 267-273



Chu-Sook Kim
Departments of Food Science and Nutrition
Won-Hyung Park
Departments of Food Science and Nutrition
Jun-Young Park
Departments of Food Science and Nutrition
Ji-Hye Kang
Departments of Food Science and Nutrition
Mi-Ock Kim
University of Ulsan, Ulsan, Department of Health Diet, Daegu Health College, Daegu
Teruo Kawada
Gwangju, South Korea, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
Hoon Yoo
University of Ulsan, Ulsan, College of Dentistry, Chosun University
In-Seob Han
Departments of Biological Science
Rina Yu
Departments of Food Science and Nutrition
Capsaicin (N-vanillyl-8-methyl-α-nonenamide), a spicy component of hot pepper, is a homovanillic acid derivative that preferentially induces certain cancer cells to undergo apoptosis and has a putative role in cancer chemoprevention. Peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, is a ligand-dependent transcription factor. PAPRγ activation results in growth arrest and/or apoptosis in a variety of cancer cells. In the present study, we investigated the potential of capsaicin to induce apoptotic cell death in human colon cancer cells and the association of PPARγ in the capsaicin action. Cell viability was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. PPARγ and vanilloid receptor type 1 (VR-1) expressions at the protein or mRNA levels were detected by western blot analysis and reverse transcription?polymerase chain reaction. Apoptotic cell death was determined by DNA fragmentation and quantified by enzyme-linked immunosorbent assay. HT-29 human colon cancer cells expressed PPARγ and VR-1. Treatment with capsaicin or the PPARγ ligand troglitazone induced apoptotic cell death in a dose-dependent manner in HT-29 human colon cancer cells. Capsaicin-induced cell death was completely blocked by bisphenol A diglycidyl ether, a specific PPARγ antagonist. Capsazepine, a specific antagonist for vanilloid receptor, did not inhibit capsaicin-induced apoptosis. Our data suggest that capsaicin-induced apoptotic cell death in HT-29 human colon cancer cells could be associated with the PPARγ pathway without the involvement of the vanilloid receptor. Capsaicin may have a beneficial effect for the treatment of colon cancer.


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Chu-Sook Kim
Won-Hyung Park
Jun-Young Park
Ji-Hye Kang
Mi-Ock Kim
Teruo Kawada
Hoon Yoo
In-Seob Han
Rina Yu
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Conclusion, Capsiacin induces programmed cell death of human colon cancer cells in vitro ( test tubes)